Designed and simulated a CPW-fed multi-band antenna on a single-layer Rogers RO4350B substrate (εr ≈ 3.66, thickness 1.6 mm) using ANSYS HFSS. The antenna was implemented as a compact CPW-fed monopole/slot structure (≤100 × 100 mm) optimized for fabrication without vias. The design was tuned to resonate at ~1.22 GHz, 1.60–1.66 GHz, and 2.20–2.23 GHz, achieving return loss (S11) ≤ −25 dB across all bands with deep impedance matching nulls approaching −30 dB, while maintaining resonance accuracy within ±3–5% of the target frequencies.